circRNA basic information
circBase ID: hsa_circ_0000745
Name: hsa_circ_SPECC1
Synonym: circ_0000745
Host Gene: SPECC1
Genomic location(hg19): chr17:20107645-20109225:+
Genomic location(hg38): chr17:20204332-20205912:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CC tissues; adjacent nontumor tissues; adjacent tissues
Cell lines:

HeLa; Caski; C33A; Siha; ECT1/E6E7
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ATF1, GLUT1, LDHA
Associated microRNA: miR-409-3p
Biological function: circ_0000745 promotes cervical cancer cell proliferation, migration, invasion, glycolysis, and in vivo tumor growth.
Molecular mechanism: circ_0000745 functions as a ceRNA that sponges miR-409-3p to modulate ATF1 expression, thereby promoting cervical cancer progression and glycolysis.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); glycolysis (promotes)
Detected method:
Q
H
Validation methods:

RT-qPCR; ISH (In Situ Hybridization); Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; RNase R Treatment; Actinomycin D / DRB Stability Assay; Transfection; Colony Formation Assay; Transwell Assay; Western Blot; Luciferase Reporter Assay; In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

circ_0000745 expression is higher in advanced-stage and positive-invasion cervical cancer samples, and circ_0000745 is proposed as a promising biomarker or therapeutic target for cervical cancer therapy.
Description:

circ_0000745 is upregulated in cervical cancer tissues and cell lines and is associated with advanced stage and invasion. Functionally, circ_0000745 promotes proliferation, migration, invasion, glycolysis, and xenograft tumor growth. Mechanistically, it acts as a ceRNA for miR-409-3p to activate ATF1, supporting its potential as a therapeutic biomarker for cervical cancer.
Confidence score:

0.7884
Other information
Title:

Circ_0000745 Promotes the Progression of Cervical Cancer by Regulating miR-409-3p/ATF1 Axis.

Journal: Cancer biotherapy & radiopharmaceuticals
Published: 2022
PubMed ID: 32644859
Study type:

combined biological and clinical study
Data availability: -
Code availability: -