circRNA basic information
circBase ID: hsa_circ_0000098
Name: hsa_circ_SLC30A7
Synonym: hsa_circRNA_100291
Host Gene: SLC30A7
Genomic location(hg19): chr1:101372407-101387397:+
Genomic location(hg38): chr1:100906851-100921841:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; adjacent non-tumor tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: FOXO1, ESR1, JUN, AR
Associated microRNA: hsa-miR-583, hsa-miR-1276
Biological function: may function as ceRNA
Molecular mechanism: ceRNA mechanism (miRNA sponge) regulating downstream genes (e.g., FOXO1, ESR1, JUN, AR)
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

RT-qPCR; Sanger Sequencing; Microarray; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circRNA_100291 (hsa_circ_0000098, SLC30A7) is down-regulated in HCC (microarray) and shows a down-regulated tendency by RT-qPCR. Bioinformatic predictions suggest it may act as a ceRNA sponging miR-583/miR-1276 to regulate hub genes such as ESR1, JUN, AR and FOXO1.
Confidence score:

0.5135
Other information
Title:

A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.

Journal: Journal of translational medicine
Published: 2018
PubMed ID: 30092792
Study type:

combined biological and clinical study
Data availability: GSE78520; GSE94508; GSE97332
Code availability: -