circRNA basic information
circBase ID: hsa_circ_0000514
Name: hsa_circ_RPPH1
Synonym: circ_0000514
Host Gene: RPPH1
Genomic location(hg19): chr14:20811305-20811436:-
Genomic location(hg38): chr14:20343146-20343277:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PDAC tissues; paired adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with tumor T stage in PDAC; potential biomarker for disease monitoring.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

ROC curve analysis indicated circ_0000514 can distinguish PDAC tissues from paired adjacent normal tissues (good AUC).
Description:

circ_0000514 is upregulated in PDAC tissues compared with paired adjacent normal tissues. Higher circ_0000514 expression is positively correlated with T stage and it shows diagnostic discrimination by ROC analysis, but it is not associated with overall survival in this cohort.
Confidence score:

0.636
Other information
Title:

circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.

Journal: Oncology letters
Published: 2022
PubMed ID: 34992688
Study type:

combined biological and clinical study
Data availability: GSE69362; GSE79634
Code availability: -