circRNA basic information
circBase ID: hsa_circ_0000520
Name: hsa_circ_RPPH1
Synonym: circ_0000520
Host Gene: RPPH1
Genomic location(hg19): chr14:20811436-20811559:-
Genomic location(hg38): chr14:20343277-20343400:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005184
MONDO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Disease DO ID:
 3498, 3587
Disease MeSH ID:
 D021441
Disease NCIt ID:
 C9120
Disease ICD11 ID:
 581089833
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PDAC tissues; paired adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Associated with tumor stage (clinicopathological characteristics) in PDAC; potential biomarker for disease monitoring.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

ROC curve analysis indicated circ_0000520 can distinguish PDAC tissues from paired adjacent normal tissues (good AUC).
Description:

circ_0000520 is upregulated in PDAC tissues relative to paired adjacent normal tissues. Its expression is positively associated with tumor stage and it shows diagnostic discrimination by ROC analysis, but it is not associated with overall survival in this study.
Confidence score:

0.636
Other information
Title:

circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.

Journal: Oncology letters
Published: 2022
PubMed ID: 34992688
Study type:

combined biological and clinical study
Data availability: GSE69362; GSE79634
Code availability: -