| Expression pattern: |
DN |
| Associated gene: |
Cx43 |
| Associated microRNA: |
miR-182, miR-203, miR-520g, miR-520h |
| Biological function: |
Potential biomarker axis for heightened-risk of breast cancer initiation; implicated in cancer-related functions including cell movement, migration and proliferation in silico. |
| Molecular mechanism: |
ceRNA/miRNA sponging with inverse dysregulation consistent with sponging of miR-182. |
| Biological pathway or process: |
ceRNA regulation (other); migration (promotes); invasion (promotes); proliferation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RNase R Treatment; RT-qPCR; RNA-seq; Clinical Sample Validation; Bioinformatics Analysis; Survival Analysis |
| Clinical significance: |
Cx43/hsa_circ_0077755/miR-182 is proposed as a biomarker predictor of heightened risk of breast cancer initiation; its dysregulation pattern associates with prognosis along initiation and progression. |
| Description: |
hsa_circ_0077755 (GJA1/Cx43-derived) is significantly down-regulated upon Cx43 silencing in the S1 3D risk-progression model and forms the study’s only validated risk-assessment axis with miR-182, consistent with a miRNA-sponging relationship. Bioinformatics analyses link the axis to cancer-related functions such as migration, invasion and proliferation, and the authors propose it as a biomarker signature for heightened risk of breast cancer initiation and prognosis patterns across progression. |
| Confidence score: |
0.6142 |