| Expression pattern: |
UP |
| Associated gene: |
ZEB1 |
| Associated microRNA: |
miR-128-3p |
| Biological function: |
promotes proliferation, invasion and EMT and inhibits apoptosis; promotes tumor growth |
| Molecular mechanism: |
circ-ABCB10 acts as a miRNA sponge for miR-128-3p to derepress ZEB1 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis |
| Clinical significance: |
higher circ-ABCB10 expression was associated with lymph-node metastasis, FIGO stage, and tumor size in CC patients |
| Description: |
circ-ABCB10 is up-regulated in cervical cancer tissues/cell lines and promotes malignant phenotypes (proliferation, invasion, EMT) while suppressing apoptosis. Mechanistically, it sponges miR-128-3p to increase ZEB1 expression, thereby enhancing tumor growth in xenograft models. |
| Confidence score: |
0.7548 |