| Expression pattern: |
DN |
| Associated gene: |
PTBP1, CDCP1 mRNA |
| Associated microRNA: |
- |
| Biological function: |
Suppresses cervical cancer cell migration and invasion and inhibits metastasis in vivo. |
| Molecular mechanism: |
Acts as a protein decoy by binding PTBP1 (via sequence 215-224), blocking PTBP1 binding to and stabilizing CDCP1 mRNA, thereby accelerating CDCP1 mRNA decay and reducing CDCP1 protein translation to suppress metastasis. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); metastasis (inhibits); mRNA stability (inhibits) |
| Detected method: |
Q
B
S
|
| Validation methods: |
circRNA-seq; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Northern Blot; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); RT-qPCR; Clinical Sample Validation; RNA-seq; Bioinformatics Analysis; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; Actinomycin D / DRB Stability Assay; Transfection; Transwell Assay; Wound Healing Assay; CCK8; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
Lower hsa_circ_0005358 expression is associated with extracervical invasion or node metastasis (FIGO stage II or more) in cervical cancer tissues; suggested as a potential therapeutic approach for metastatic cervical cancer. |
| Description: |
hsa_circ_0005358 is down-regulated in cervical cancer, especially in extracervical metastasis-associated tissues, and functions as a metastasis suppressor. It binds PTBP1 (via sequence 215-224) to block PTBP1-mediated stabilization of CDCP1 mRNA, promoting CDCP1 mRNA decay and lowering CDCP1 protein, thereby inhibiting migration/invasion and in vivo metastasis. |
| Confidence score: |
0.8483 |