circRNA basic information
circBase ID: -
Name: ebv_circ_LMP2
Synonym: circLMP2_E8_E2
Host Gene: LMP2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus and cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007243
MONDO name: Burkitt lymphoma
Disease details: Burkitt’s lymphoma
Disease DO ID:
 8584
Disease MeSH ID:
 D002051
Disease NCIt ID:
 C2912
Disease ICD11 ID:
 2100138081
Disease OMIM ID:
 113970
Species: Virus
Species details: Human gammaherpesvirus 4 / Epstein-Barr virus
Tissue specimen:

-
Cell lines:

Akata; Mutu I; Jijoye; JY; IB4
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: LMP2B
Associated microRNA: -
Biological function: unknown
Molecular mechanism: unknown
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; divergent primers PCR; Back-Splice Junction PCR; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Sanger Sequencing
Clinical significance:

-
Description:

circLMP2_E8_E2 is an EBV reactivation-associated circRNA formed by exon 8-to-exon 2 backsplicing at the LMP2 locus, with context-specific expression in reactivation models. It shows low but significant cytoplasmic localization and its structure likely includes the coding region of LMP2B, raising the possibility it represents a novel circular isoform; no miRNA sponge evidence was found for LMP2 exons 2-8.
Confidence score:

0.5246
Other information
Title:

The Epstein Barr virus circRNAome.

Journal: PLoS pathogens
Published: 2018
PubMed ID: 30080890
Study type:

biological research
Data availability: GSE52490
Code availability: -