circRNA basic information
circBase ID: hsa_circ_0001228
Name: hsa_circ_MFNG
Synonym: hsa_circ_001888
Host Gene: MFNG
Genomic location(hg19): chr22:37868480-37870715:-
Genomic location(hg38): chr22:37472442-37474677:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

GC tissues; paired adjacent normal tissues; plasma samples
Cell lines:

AGS; MKN-45; GES-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: May be involved in GC development; suggested as a diagnostic biomarker.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

May serve as a potential biomarker for GC diagnosis; AUC in tissues 0.654 and in plasma 0.66; associations with differentiation (tissues) and with serum CEA and CA19-9 levels (plasma).
Description:

hsa_circ_001888 (MFNG-derived) is significantly down-regulated in gastric cancer cell lines, tumor tissues, and patient plasma, and shows diagnostic potential (ROC AUC ~0.65-0.66). Its expression associates with tumor differentiation in tissues and with serum CEA/CA19-9 status in plasma, but no molecular mechanism was experimentally defined in this study.
Confidence score:

0.559
Other information
Title:

Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance.

Journal: Journal of clinical laboratory analysis
Published: 2021
PubMed ID: 34398999
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -