| Expression pattern: |
UP |
| Associated gene: |
SIRT1, p53 |
| Associated microRNA: |
miR-181a |
| Biological function: |
promotes glioma cell proliferation, invasion and migration; enhances temozolomide chemoresistance; supports tumor growth in vivo |
| Molecular mechanism: |
Acts as a ceRNA sponge for miR-181a, thereby modulating SIRT1 expression |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); migration (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
- |
| Description: |
hsa_circ_0076248 is up-regulated in glioma/GBM tissues and cell lines and promotes oncogenic phenotypes (proliferation, migration/invasion) and temozolomide resistance. Mechanistically, it functions as a miR-181a sponge to regulate the miR-181a/SIRT1 axis and affects p53 and SIRT1 protein levels. |
| Confidence score: |
0.5762 |