| Expression pattern: |
UP |
| Associated gene: |
ER-alpha, ER-beta |
| Associated microRNA: |
miR-141-5p |
| Biological function: |
promotes endometriosis progression by enhancing proliferation, invasion, and migration; knockdown reduces lesion size in vivo |
| Molecular mechanism: |
hsa_circ_0063526 binds (sponges) miR-141-5p; impacts EMT markers and downregulates estrogen receptors |
| Biological pathway or process: |
EMT (promotes); migration (promotes); invasion (promotes); proliferation (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; EdU Staining; ELISA; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); Clinical Sample Validation |
| Clinical significance: |
possible biomarkers and therapeutic targets for endometriosis |
| Description: |
hsa_circ_0063526 is up-regulated in endometriosis ectopic lesions. It promotes endometriosis cell proliferation, invasion and migration by binding miR-141-5p and enhancing EMT-related changes, and its knockdown reduces lesion size and suppresses estrogen receptor expression in vivo. |
| Confidence score: |
0.713 |