| Expression pattern: |
UP |
| Associated gene: |
ITGA1 |
| Associated microRNA: |
miR-876-3p |
| Biological function: |
Promotes temozolomide resistance, cell proliferation, invasion and migration, and inhibits apoptosis in TMZ-resistant GBM cells; exosomal circ_0043949 reinforces TMZ resistance in vivo. |
| Molecular mechanism: |
Exosomal circ_0043949 functions as a miR-876-3p sponge to upregulate ITGA1 expression, thereby promoting TMZ resistance in GBM. |
| Biological pathway or process: |
chemoresistance (promotes); drug resistance (promotes); proliferation (promotes); apoptosis (inhibits); invasion (promotes); migration (promotes); ceRNA regulation (promotes); other pathway/process (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Clinical Sample Validation; Transfection; MTT; EdU Staining; Annexin V/PI Flow Cytometry; Transwell Assay; Wound Healing Assay; Western Blot; Luciferase Reporter Assay; RNA Pull-Down; Bioinformatics Analysis; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
High circ_0043949 levels were associated with WHO grade and tumor size of patients with GBM; circ_0043949 may be a target for enhancing TMZ sensitivity. |
| Description: |
Hsa_circ_0043949/circ_0043949 is upregulated in TMZ-resistant GBM tissues, cells, and exosomes. It promotes temozolomide resistance by acting as a miR-876-3p sponge to increase ITGA1 expression, thereby enhancing proliferation, invasion, migration, and reducing apoptosis. Exosomal circ_0043949 derived from TMZ-resistant GBM cells reinforces TMZ resistance in xenograft models and may represent a therapeutic target for sensitizing GBM to TMZ. |
| Confidence score: |
0.8006 |