| Expression pattern: |
DN |
| Associated gene: |
DOK7 |
| Associated microRNA: |
miR-661 |
| Biological function: |
Suppresses NSCLC development by inhibiting cell viability and proliferation, promoting apoptosis, and promoting G0/G1 phase entry (reducing S phase arrest). |
| Molecular mechanism: |
Acts as a miRNA sponge (ceRNA) for miR-661, thereby elevating DOK7 expression. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); cell cycle (other); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Luciferase Reporter Assay; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
circ_0001947 might be a potential new biomarker for the treatment of NSCLC. |
| Description: |
In NSCLC, circ_0001947 is down-regulated and functions as a tumor suppressor. It sponges miR-661 to relieve repression of DOK7, thereby inhibiting viability/proliferation and promoting apoptosis with cell-cycle effects. |
| Confidence score: |
0.6521 |