| Expression pattern: |
DN |
| Associated gene: |
CD74 |
| Associated microRNA: |
hsa_miR_760 |
| Biological function: |
Potentially regulates osteosarcoma pathogenesis via a ceRNA network (sponging miRNA) involving CD74. |
| Molecular mechanism: |
ceRNA mechanism in which hsa_circ_0001753 potentially sponges hsa_miR_760 to regulate CD74. |
| Biological pathway or process: |
ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; Clinical Sample Validation |
| Clinical significance: |
hsa_circ_0001753/has_miR_760/CD74 network may serve as a target for the early diagnosis of and targeted therapy for OS. |
| Description: |
hsa_circ_0001753 is down-regulated in osteosarcoma cell lines versus osteoblasts. The study proposes and validates a ceRNA network where hsa_circ_0001753 interacts with hsa-miR-760 and is linked to reduced CD74 expression, suggesting a role in osteosarcoma pathogenesis and potential diagnostic/therapeutic relevance. |
| Confidence score: |
0.4997 |