| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
hsa-miR-502-5p, hsa-let-7a-5p, hsa-let-7b-5p, hsa-let-7c-5p, hsa-let-7f-5p |
| Biological function: |
Promotes hVICs proliferation and migration; inhibits apoptosis; promotes cell cycle progression. |
| Molecular mechanism: |
Predicted miRNA sponge function in the cytoplasm (bioinformatics prediction). |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); cell cycle (promotes); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; FISH / smFISH |
| Clinical significance: |
hsa_circ_0000437 has diagnostic value for RVHD (AUC up to 0.957 with high sensitivity and specificity). |
| Description: |
hsa_circ_0000437 (from the CORO1C locus) is up-regulated in the plasma of RVHD patients and shows strong diagnostic performance by ROC analysis. In hVICs, it promotes proliferation and migration, inhibits apoptosis, and affects cell-cycle distribution; it is cytoplasm-localized and predicted to act as a miRNA sponge (e.g., hsa-miR-502-5p and let-7 family members). |
| Confidence score: |
0.7486 |