circRNA basic information
circBase ID: hsa_circ_0000467
Name: hsa_circ_SKA3
Synonym: circ_0000467
Host Gene: SKA3
Genomic location(hg19): chr13:21742126-21742538:-
Genomic location(hg38): chr13:21167987-21168399:-
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: Colorectal cancer
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

CRC tissues; adjoining healthy tissues; tumor tissues; adjacent normal tissues; xenograft tumor tissues
Cell lines:

HCT116; LoVo; NCM460
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: TYRO3, SKA3, E-cadherin, N-cadherin, Vimentin, ki-67
Associated microRNA: miR-330-5p
Biological function: Circ_0000467 promotes CRC cell proliferation, migration, invasion, glycolysis, metastasis-related marker changes, cell cycle progression, and tumor growth, while inhibiting apoptosis.
Molecular mechanism: Circ_0000467 acts as a cytoplasmic miRNA sponge for miR-330-5p and upregulates TYRO3, thereby promoting CRC malignant progression and glycolysis.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); apoptosis (inhibits); cell cycle (promotes); glycolysis (promotes); ceRNA regulation (promotes); other pathway/process (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; RT-qPCR; Microarray; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Bioinformatics Analysis
Clinical significance:

Circ_0000467 may provide a novel molecular target for CRC therapy.
Description:

Circ_0000467 is upregulated in CRC tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC proliferation, migration, invasion, glycolysis, cell cycle progression, and tumor growth by sponging miR-330-5p to increase TYRO3 expression, while suppressing apoptosis.
Confidence score:

0.8254
Other information
Title:

Circ_0000467 Exerts an Oncogenic Role in Colorectal Cancer via miR-330-5p-Dependent Regulation of TYRO3.

Journal: Biochemical genetics
Published: 2022
PubMed ID: 35039980
Study type:

combined biological and clinical study
Data availability: GSE142837; GSE138589; https:// doi. org/ 10. 1007/ s10528-021-10171-7
Code availability: -