| Expression pattern: |
UP |
| Associated gene: |
SALL4 |
| Associated microRNA: |
miR-1305 |
| Biological function: |
Promotes LUAD cell proliferation, migration, invasion, glycolysis and tumor formation, and inhibits apoptosis. |
| Molecular mechanism: |
CircSFMBT2 acts as a miR-1305 sponge and positively modulates SALL4 expression through the miR-1305/SALL4 axis. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); glycolysis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Transfection; EdU Staining; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; IHC (Immunohistochemistry); Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Upregulated circSFMBT2 is related to advanced TNM stage and poor prognosis, and may provide a diagnostic and prognostic marker for LUAD. |
| Description: |
CircSFMBT2 is an upregulated oncogenic circRNA in LUAD and high expression is associated with advanced TNM stage and poorer overall survival. Functionally, it promotes proliferation, migration, invasion, glycolysis and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circSFMBT2 sponges miR-1305 to increase SALL4 expression, forming a circSFMBT2/miR-1305/SALL4 regulatory axis. |
| Confidence score: |
0.7976 |