circRNA basic information
circBase ID: -
Name: ebv_circ_EBNA
Synonym: circEBNA_W1_C1
Host Gene: EBNA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: nucleus
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007243
MONDO name: Burkitt lymphoma
Disease details: Burkitt’s lymphoma
Disease DO ID:
 8584
Disease MeSH ID:
 D002051
Disease NCIt ID:
 C2912
Disease ICD11 ID:
 2100138081
Disease OMIM ID:
 113970
Species: Virus
Species details: Human gammaherpesvirus 4 / Epstein-Barr virus
Tissue specimen:

-
Cell lines:

Mutu III; Jijoye; JY; IB4; Akata; Mutu I; Sav I; SNU719; YCCEL1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: unknown
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RNase R Treatment; divergent primers PCR; Back-Splice Junction PCR; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Sanger Sequencing
Clinical significance:

-
Description:

circEBNA_W1_C1 is an EBV circRNA expressed from the Cp latency promoter via W1-to-C1 backsplicing, detected mainly in type III latency cell models and enriched in the nucleus. The paper suggests it may contribute to type III latency-specific regulatory processes (e.g., Cp-driven transcript diversity or Cp promoter regulation), but no definitive mechanism is established.
Confidence score:

0.5246
Other information
Title:

The Epstein Barr virus circRNAome.

Journal: PLoS pathogens
Published: 2018
PubMed ID: 30080890
Study type:

combined biological and clinical study
Data availability: GSE52490
Code availability: -