circRNA basic information
circBase ID: hsa_circ_0000730
Name: -
Synonym: circ_0000730
Host Gene: -
Genomic location(hg19): chr17:1457063-1457152:-
Genomic location(hg38): chr17:1553769-1553858:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

CC tissues; adjacent normal tissues
Cell lines:

HeLa; CaSki; SiHa; C-33A; SW756; H8; HEK-293 T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: PTEN
Associated microRNA: miR-942-5p
Biological function: inhibits cell proliferation; inhibits migration; inhibits invasion
Molecular mechanism: ceRNA mechanism by sponging miR-942-5p to increase PTEN expression
Biological pathway or process:

proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Clinical Sample Validation; Survival Analysis; Luciferase Reporter Assay; Transfection; BrdU; Transwell Assay; Western Blot; Bioinformatics Analysis
Clinical significance:

down-regulation of circ_0000730 was associated with the poor survival of CC patients; low expression of circ_0000730 was significantly correlated with high FIGO stage and poor tissue differentiation
Description:

hsa_circ_0000730 (circ_0000730) is significantly down-regulated in cervical cancer tissues and cell lines, and its low expression is associated with worse overall survival. Functionally, circ_0000730 suppresses proliferation, migration, and invasion of cervical cancer cells by acting as a ceRNA that sponges miR-942-5p and thereby increases PTEN expression.
Confidence score:

0.7325
Other information
Title:

Circular RNA hsa_circ_0000730 restrains cell proliferation, migration, and invasion in cervical cancer through miR-942-5p/PTEN axis.

Journal: The Kaohsiung journal of medical sciences
Published: 2021
PubMed ID: 34562344
Study type:

combined biological and clinical study
Data availability: GSE113696
Code availability: -