circRNA basic information
circBase ID: hsa_circ_0026337
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr12:52180325-52188425:+
Genomic location(hg38): chr12:51786541-51794641:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissue; adjacent healthy tissue; tumor-adjacent tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: MAPK8, IGF1R, GRB2, ITCH
Associated microRNA: miR-1193, miR-197-3p, miR-3605-5p, miR-433-3p, miR-652-3p
Biological function: Acts as a predicted tumor suppressor ceRNA in NSCLC; low expression may increase hsa-miR-197-3p and promote tumor growth.
Molecular mechanism: Predicted ceRNA mechanism: hsa_circ_0026337 sponges miRNAs, especially hsa-miR-197-3p, thereby affecting translation/expression of proteins such as MAPK8, IGF1R, GRB2, and ITCH.
Biological pathway or process:

ceRNA regulation (other); proliferation (inhibits); cell cycle (other); inflammation (other); PI3K/AKT (other); AMPK (other)
Detected method:
M
Validation methods:

Microarray; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Low expression was significantly associated with shortened survival time in NSCLC, suggesting potential prognostic relevance.
Description:

hsa_circ_0026337 was downregulated in NSCLC tissues based on GEO circRNA microarray datasets. The study predicts that hsa_circ_0026337 functions through a ceRNA network involving miR-197-3p and protein-coding targets such as MAPK8, IGF1R, GRB2, and ITCH, with low expression linked to poorer survival.
Confidence score:

0.348
Other information
Title:

Bioinformatics Analysis Predicts hsa_circ_0026337/miR-197-3p as a Potential Oncogenic ceRNA Network for Non-Small Cell Lung Cancers.

Journal: Anti-cancer agents in medicinal chemistry
Published: 2022
PubMed ID: 34254931
Study type:

bioinformatics study
Data availability: GSE158695; GSE112214; GSE101684; TCGA; UALCAN; CSCD; ENCORI
Code availability: -