circRNA basic information
circBase ID: hsa_circ_0023642
Name: hsa_circ_UVRAG
Synonym: -
Host Gene: UVRAG
Genomic location(hg19): chr11:75727858-75728024:+
Genomic location(hg38): chr11:76016814-76016980:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004986
MONDO name: urinary bladder carcinoma
Disease details: bladder cancer
Disease DO ID:
 4007
Disease MeSH ID:
 -
Disease NCIt ID:
 C4912
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

bladder tumor tissues; normal bladder tissues; orthotopic bladder tumor tissues
Cell lines:

J82; UMUC3
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UN
Associated gene: ERalpha, EGFR
Associated microRNA: miR-490-5p
Biological function: promotes bladder cancer cell invasion and metastasis; ERalpha-mediated downregulation of circ_0023642 suppresses BCa progression
Molecular mechanism: ERalpha transcriptionally represses the host gene UVRAG to reduce circ_0023642; circ_0023642 sponges miR-490-5p, thereby modulating EGFR expression to regulate invasion/metastasis
Biological pathway or process:

ceRNA regulation (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; RNA Pull-Down; Luciferase Reporter Assay; ChIP / ChIP-seq; Transfection; Transwell Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis
Clinical significance:

-
Description:

In bladder cancer cells, circ_0023642 acts as a pro-invasive circRNA by sponging miR-490-5p, thereby relieving repression of EGFR and promoting invasion/metastasis. ERalpha suppresses BCa progression by transcriptionally downregulating the host gene UVRAG, which reduces circ_0023642 and activates the miR-490-5p-mediated inhibition of EGFR.
Confidence score:

0.7754
Other information
Title:

ERalpha-mediated alterations in circ_0023642 and miR-490-5p signaling suppress bladder cancer invasion.

Journal: Cell death & disease
Published: 2019
PubMed ID: 31455760
Study type:

combined biological and clinical study
Data availability: TCGA
Code availability: -