circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circular RNA Pvt1 oncogene
Host Gene: PVT1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005075
MONDO name: thyroid gland papillary carcinoma
Disease details: papillary thyroid carcinoma
Disease DO ID:
 3969
Disease MeSH ID:
 -
Disease NCIt ID:
 C4035
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

PTC tumor samples; matching contralateral normal samples
Cell lines:

K1; IHH-4; BCPAP; TPC-1; Nthy-ori 3-1
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: VEGFA, Wnt/beta-catenin signaling pathway
Associated microRNA: miR-195
Biological function: Promotes PTC cell proliferation, migration, and invasion.
Molecular mechanism: Acts as a ceRNA/miRNA sponge for miR-195 to upregulate VEGFA and activate Wnt/beta-catenin signaling.
Biological pathway or process:

Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; CCK8; EdU Staining; Transwell Assay; Luciferase Reporter Assay; Western Blot; Bioinformatics Analysis; Survival Analysis
Clinical significance:

High expression of circPVT1 was related to tumor size, TNM stage, and lymph node metastasis; no significant correlation with overall survival in this cohort; proposed as biomarker/therapeutic target.
Description:

circPVT1 is up-regulated in papillary thyroid carcinoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it sponges miR-195 to increase VEGFA expression and activate Wnt/beta-catenin signaling.
Confidence score:

0.7113
Other information
Title:

Circular RNA Pvt1 oncogene (CircPVT1) promotes the progression of papillary thyroid carcinoma by activating the Wnt/beta-catenin signaling pathway and modulating the ratio of microRNA-195 (miR-195) to vascular endothelial growth factor A (VEGFA) expression.

Journal: Bioengineered
Published: 2021
PubMed ID: 34927541
Study type:

combined biological and clinical study
Data availability: The data used to support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -