circRNA basic information
circBase ID: hsa_circ_0000284
Name: hsa_circ_HIPK3
Synonym: circHIPK3
Host Gene: HIPK3
Genomic location(hg19): chr11:33307958-33309057:+
Genomic location(hg38): chr11:33286412-33287511:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung carcinoma
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

NCI-H1299; NCI-H2170; 293T; H1299; H827; H1975; H2170; H520; H1650
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: IGF1
Associated microRNA: miR-379
Biological function: promotes NSCLC cell proliferation
Molecular mechanism: circHIPK3 acts as a miRNA sponge for miR-379 to regulate IGF1 expression
Biological pathway or process:

proliferation (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Nuclear-Cytoplasmic Fractionation; RT-qPCR; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Western Blot; ELISA; Bioinformatics Analysis
Clinical significance:

might be a potential tumor biomarker for NSCLC
Description:

In NSCLC cell lines, circHIPK3 promotes cell proliferation. Mechanistically, it functions as a ceRNA that sponges miR-379, thereby relieving repression of IGF1 and increasing IGF1 expression.
Confidence score:

0.7435
Other information
Title:

[Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1].

Journal: Zhongguo fei ai za zhi = Chinese journal of lung cancer
Published: 2017
PubMed ID: 28738961
Study type:

biological research
Data availability: -
Code availability: -