| Expression pattern: |
UP |
| Associated gene: |
TGFBR2, AKT |
| Associated microRNA: |
miR-606 |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion; promotes tumor growth in vivo; promotes EMT |
| Molecular mechanism: |
circSEC24A sponges miR-606 to relieve repression of TGFBR2, thereby activating AKT signaling. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); PI3K/AKT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Cell Cycle Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; H&E Staining; Bioinformatics Analysis; Clinical Sample Validation; Microarray |
| Clinical significance: |
circSEC24A might be used as a critical biomarker influencing the early diagnosis and prognosis of pancreatic cancer. |
| Description: |
circSEC24A is up-regulated in pancreatic cancer tissues and cell lines and promotes pancreatic cancer cell proliferation, migration, invasion, EMT and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-606 to de-repress TGFBR2, which contributes to activation of PI3K/AKT signaling. |
| Confidence score: |
0.7995 |