| Expression pattern: |
DN |
| Associated gene: |
PDCD4 |
| Associated microRNA: |
miR-21-5p |
| Biological function: |
inhibits proliferation, migration and invasion; promotes apoptosis; restrains osteosarcoma progression |
| Molecular mechanism: |
ceRNA mechanism: circ_0008259 competitively binds miR-21-5p to up-regulate PDCD4 |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; FISH / smFISH; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
may be a promising biomarker and therapeutic target for OS sufferers |
| Description: |
circ_0008259 is down-regulated in osteosarcoma tissues and cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA that sponges miR-21-5p, thereby relieving miR-21-5p-mediated repression of PDCD4 and inhibiting malignant phenotypes while promoting apoptosis. |
| Confidence score: |
0.8058 |