| Expression pattern: |
DN |
| Associated gene: |
PTEN |
| Associated microRNA: |
miR-885-5p |
| Biological function: |
Suppresses gastric cancer cell proliferation, migration, invasion, tumor growth and metastasis. |
| Molecular mechanism: |
Acts as a miRNA sponge for miR-885-5p to upregulate PTEN and suppress PI3K/AKT signaling. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); PI3K/AKT (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
Patients in the circRAB31 high group have a better survival outcome than those in the circRAB31 low group. |
| Description: |
circRAB31 is downregulated in gastric cancer and functions as a tumor suppressor. It sponges miR-885-5p to relieve repression of PTEN, thereby inhibiting PI3K/AKT signaling and reducing proliferation, migration, invasion, tumor growth and metastasis. |
| Confidence score: |
0.8792 |