| Expression pattern: |
UP |
| Associated gene: |
EGFR, IGF-1R |
| Associated microRNA: |
miR-7 |
| Biological function: |
Promotes CRC cell proliferation and invasion; facilitates CRC progression. |
| Molecular mechanism: |
CDR1as partially blocks (sponges) miR-7, thereby positively regulating EGFR and IGF-1R expression. |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); cell cycle (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Colony Formation Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
High CDR1as expression is associated with tumor size, T stage, lymph node metastasis, and poor overall survival (OS) in CRC patients. |
| Description: |
CDR1as is up-regulated in colorectal cancer and high expression is associated with worse overall survival. Functionally, CDR1as promotes CRC proliferation and invasion by partially antagonizing miR-7, thereby sustaining EGFR and IGF-1R expression. |
| Confidence score: |
0.648 |