| Expression pattern: |
UP |
| Associated gene: |
PLK2, TAp73 |
| Associated microRNA: |
miR-520g-3p |
| Biological function: |
Suppresses osteosarcoma progression; inhibits proliferation, migration and invasion; promotes apoptosis; affects cell cycle (G2 phase arrest upon silencing). |
| Molecular mechanism: |
Acts as a sponge (ceRNA) for miR-520g-3p to regulate PLK2 (and TAp73) expression. |
| Biological pathway or process: |
ceRNA regulation (inhibits); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); cell cycle (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
This study shows circ_0102049 acts as a tumor suppressor in osteosarcoma models. Silencing circ_0102049 promotes tumor growth and enhances MG63 cell proliferation, migration and invasion while reducing apoptosis, mainly through a ceRNA mechanism involving miR-520g-3p and downstream PLK2 (and TAp73). |
| Confidence score: |
0.6276 |