| Expression pattern: |
UP |
| Associated gene: |
LRRC1, YY1, eIF4A3, Ago2 |
| Associated microRNA: |
miR-432-5p |
| Biological function: |
promotes proliferation, migration and invasion; promotes xenograft growth; promotes EMT |
| Molecular mechanism: |
circ-ZNF609 acts as a ceRNA to sponge miR-432-5p, relieving repression of LRRC1; YY1 promotes circ-ZNF609 transcription; eIF4A3 promotes circ-ZNF609 circular formation by binding its pre-mRNA |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); ChIP / ChIP-seq; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation |
| Clinical significance: |
High circ-ZNF609 expression was associated with advanced TNM stage, lymph node invasion, and inferior overall survival, and was an independent risk factor for unfavorable prognosis; ROC analysis supported prognostic biomarker potential. |
| Description: |
circ-ZNF609 is up-regulated in cholangiocarcinoma and functions as an oncogenic circRNA that promotes proliferation, migration, invasion and xenograft growth. Mechanistically, it sponges miR-432-5p to up-regulate LRRC1, while YY1 enhances its transcription and eIF4A3 promotes its circularization by binding the pre-mRNA. |
| Confidence score: |
0.849 |