circRNA basic information
circBase ID: hsa_circ_0072387
Name: hsa_circ_HMGCS1
Synonym: circ_0072387
Host Gene: HMGCS1
Genomic location(hg19): chr5:43294157-43297268:-
Genomic location(hg38): chr5:43294055-43297166:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004958
MONDO name: oral cavity squamous cell carcinoma
Disease details: oral squamous cell carcinoma / OSCC
Disease DO ID:
 0050866
Disease MeSH ID:
 -
Disease NCIt ID:
 C4833
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

OSCC tissues; paired adjacent normal tissues
Cell lines:

SCC25; SCC15; CAL27; HOK
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: MMP2, BCL2, PTEN
Associated microRNA: hsa-miR-129-3p, hsa-miR-141-3p, hsa-miR-29-3p
Biological function: Lower hsa_circ_0072387 expression is associated with larger tumor diameter, advanced T stage, advanced TNM stage, shorter postoperative survival time, and potential diagnostic value in OSCC; the authors suggest it may act as a suppressor gene and potential diagnostic biomarker.
Molecular mechanism: Bioinformatics predicted that hsa_circ_0072387 may bind hsa-miR-129-3p, hsa-miR-141-3p, and hsa-miR-29-3p and participate in a circRNA-miRNA-mRNA network involving MMP2, BCL2, and PTEN, with enrichment in tumor-related pathways including MAPK signaling.
Biological pathway or process:

ceRNA regulation (other); MAPK (other); Hippo/YAP (other); other pathway/process (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Cohort Study
Clinical significance:

hsa_circ_0072387 expression is associated with TNM stage, tumor diameter, T stage, overall survival, and diagnostic performance for OSCC with an AUC of 0.746; lower expression predicts worse postoperative survival.
Description:

hsa_circ_0072387 is significantly down-regulated in OSCC tissues and cell lines. Its lower expression is associated with more aggressive clinicopathological features and worse survival, while ROC analysis suggests diagnostic potential. Bioinformatics predicts a possible miRNA-mediated regulatory network involving hsa-miR-129-3p, hsa-miR-141-3p, hsa-miR-29-3p, and downstream targets such as MMP2, BCL2, and PTEN.
Confidence score:

0.5339
Other information
Title:

Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma.

Journal: Oral diseases
Published: 2019
PubMed ID: 30908839
Study type:

combined biological and clinical study
Data availability: Supporting Information
Code availability: -