circRNA basic information
circBase ID: hsa_circ_0072389
Name: hsa_circ_HMGCS1
Synonym: -
Host Gene: HMGCS1
Genomic location(hg19): chr5:43294157-43299077:-
Genomic location(hg38): chr5:43294055-43298975:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

glioma tissues; normal tissues
Cell lines:

U251
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: IKBIP, AGO2
Associated microRNA: miR-338-5p
Biological function: Aggravates glioma by promoting IKBIP expression via miR-338-5p sponging, leading to activation of NF-kappaB, JAK/STAT and TGFbeta/SMAD signaling pathways.
Molecular mechanism: Predicted ceRNA mechanism: hsa_circ_0072389 binds to miR-338-5p to hinder silencing of IKBIP mRNA, increasing IKBIP and activating downstream pathways.
Biological pathway or process:

NF-kappaB (promotes); JAK/STAT (promotes); TGF-beta/SMAD (promotes); ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; Western Blot
Clinical significance:

-
Description:

This study proposes that hsa_circ_0072389 (from host gene HMGCS1) aggravates glioma by sponging miR-338-5p, thereby relieving repression of IKBIP and promoting downstream NF-kappaB/JAK/STAT/TGFbeta-SMAD signaling.
Confidence score:

0.4474
Other information
Title:

hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP.

Journal: Aging
Published: 2021
PubMed ID: 34897031
Study type:

combined biological and bioinformatics study
Data availability: GSE146463; GSE4290; GSE139031; GSE25632; GSE103228; GSE65626
Code availability: -