| Expression pattern: |
UP |
| Associated gene: |
IGF1R, AGO2 |
| Associated microRNA: |
miR-339-3p |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion; inhibits apoptosis; promotes tumor growth and lung metastasis; promotes cisplatin resistance |
| Molecular mechanism: |
circDOCK1 acts as a miRNA sponge for miR-339-3p to regulate IGF1R expression, affecting tumor progression and cisplatin sensitivity |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); chemoresistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; MTT; In Vivo Animal Model; TUNEL; IHC (Immunohistochemistry); Western Blot; H&E Staining; Survival Analysis; ROC Analysis; Bioinformatics Analysis; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
Overall survival was unfavorable in OS patients with higher circDOCK1 levels; serum circDOCK1 showed diagnostic value (AUC 0.751). |
| Description: |
circDOCK1 is up-regulated in osteogenic sarcoma tissues/cells and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion, tumor growth/metastasis) and reduces apoptosis, and it contributes to cisplatin resistance by sponging miR-339-3p to upregulate IGF1R. |
| Confidence score: |
0.8999 |