circRNA basic information
circBase ID: hsa_circ_0101432
Name: hsa_circ_RPPH1
Synonym: -
Host Gene: RPPH1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; matched normal liver tissues / matched non-tumor tissues
Cell lines:

HL-7702; Huh-7; SK-HEP-1; HepG2; HLE
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: MAPK1
Associated microRNA: miR-1258, miR-622
Biological function: Promotes HCC cell proliferation, colony formation and invasion; inhibits apoptosis; promotes tumor growth in vivo.
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-1258 and miR-622, thereby increasing MAPK1 mRNA/protein expression.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); invasion (promotes); apoptosis (inhibits); MAPK (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; RNase R Treatment; Transfection; RNA Pull-Down; Luciferase Reporter Assay; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; In Vivo Animal Model; Western Blot; Bioinformatics Analysis; Clinical Sample Validation
Clinical significance:

-
Description:

hsa_circ_0101432 is up-regulated in HCC tissues/cell lines and promotes HCC progression. Mechanistically, it sponges miR-1258 and miR-622 to relieve repression of MAPK1, enhancing proliferation and invasion while inhibiting apoptosis, and it promotes tumor growth in a nude-mouse xenograft model.
Confidence score:

0.8122
Other information
Title:

Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622.

Journal: Cell cycle (Georgetown, Tex.)
Published: 2019
PubMed ID: 31095447
Study type:

combined biological and clinical study
Data availability: GSE78520; GSE94508; GSE97332; Supplementary Table 1; Supplementary Table 2
Code availability: -