| Expression pattern: |
UP |
| Associated gene: |
TLR4 |
| Associated microRNA: |
hsa-miR-4268, hsa-miR-764, hsa-miR-3907 |
| Biological function: |
Induces abnormal autophagy and autophagic death in cardiomyocytes; inhibits H9C2 cell proliferation in the exosome-treated condition; promotes MM-related myocardial damage. |
| Molecular mechanism: |
ceRNA mechanism: circ-G042080 sponges hsa-miR-4268 to regulate TLR4 and activate Toll-like receptor signaling, increasing autophagy in cardiomyocytes. |
| Biological pathway or process: |
Toll-like receptor signaling (promotes); autophagy (promotes); proliferation (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; CCK8; IF (Immunofluorescence); Western Blot; Electron microscopy; ROC Analysis; Survival Analysis |
| Clinical significance: |
High circ-G042080 in serum exosomes correlates with myocardial damage markers and may serve as a biomarker and independent prognostic indicator in MM-related myocardial damage (ROC AUC 0.909; cutoff 2.18). |
| Description: |
circ-G042080 is up-regulated in serum exosomes from MM patients and correlates with MM-related myocardial damage severity. It likely sponges hsa-miR-4268 to increase TLR4 and activate Toll-like receptor signaling, promoting autophagy and cardiomyocyte injury; higher levels predict poorer survival. |
| Confidence score: |
0.7617 |