circRNA basic information
circBase ID: -
Name: mmu_circ_Foxo3
Synonym: -
Host Gene: Foxo3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004994
MONDO name: cardiomyopathy
Disease details: cardiomyopathy
Disease DO ID:
 0050700
Disease MeSH ID:
 D009202
Disease NCIt ID:
 C34830
Disease ICD11 ID:
 282225286
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

heart tissues / heart tissue
Cell lines:

mouse cardiac fibroblasts
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Decreased circ-Foxo3 levels were associated with improved cardiac function in the TAC cardiomyopathy model after Ganoderma spore oil treatment.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Transfection; In Vivo Animal Model
Clinical significance:

-
Description:

In the TAC mouse model of pressure overload-induced cardiomyopathy/heart failure, Ganoderma spore oil treatment reduced cardiac circ-Foxo3 expression. This reduction was also observed in mouse cardiac fibroblasts in a dose- and time-dependent manner.
Confidence score:

0.3513
Other information
Title:

The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression.

Journal: Oncoscience
Published: 2016
PubMed ID: 27713910
Study type:

biological research
Data availability: -
Code availability: -