circRNA basic information
circBase ID: hsa_circ_0090002
Name: hsa_circ_PHKA2
Synonym: circPHKA2
Host Gene: hsa-miR-574-5p
 
 
 
Disease basic information
DO ID:
 936
DO name: brain disease
Disease details: Human Brain Microvascular Endothelial Cell Injuries
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: HBMEC
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-574-5p
Biological function: circPHKA2 Prompted Proliferation, Migration, and Neovascularization of HBMEC after OGD
Molecular mechanism: circPHKA2 Inhibited Apoptosis, ER Stress, and Oxidative Stress of HBMEC after OGD
Survival: -
Supported No.:
 1
Description:

circPHKA2 could protect HBMEC against OGD-induced cerebral stroke model via the miR-574-5p/SOD2 axis, suggesting circPHKA2 as a novel and promising candidate in ischemic brain injury.
Other information
Title:

Circular RNA circPHKA2 Relieves OGD-Induced Human Brain Microvascular Endothelial Cell Injuries through Competitively Binding miR-574-5p to Modulate SOD2.

Journal: Oxid Med Cell Longev
Published: 2021/11/19
PubMed ID: 34790286