| Expression pattern: |
UP |
| Associated gene: |
KMT5C |
| Associated microRNA: |
miR-29a |
| Biological function: |
promotes HCC cell proliferation, migration and invasion; inhibits apoptosis; promotes xenograft tumor growth and lung metastasis in vivo |
| Molecular mechanism: |
ceRNA mechanism: circMYLK sponges miR-29a to relieve repression of KMT5C |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes) |
| Detected method: |
Q
H
|
| Validation methods: |
RT-qPCR; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; IF (Immunofluorescence); IHC (Immunohistochemistry); H&E Staining; In Vivo Animal Model; Clinical Sample Validation; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
elevated circMYLK expression was related to poor overall survival rate in HCC patients; associated with tumor size, differentiation, and TNM classification |
| Description: |
circMYLK (hsa_circ_0002768) is up-regulated in HCC tissues and cell lines and predicts worse overall survival. It promotes HCC proliferation, migration/invasion, and metastasis while inhibiting apoptosis by sponging miR-29a to increase KMT5C expression. |
| Confidence score: |
0.7739 |