circRNA basic information
circBase ID: -
Name: hsa_circ_NRIP1
Synonym: NRIP1
Host Gene: NRIP1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018874
MONDO name: acute myeloid leukemia
Disease details: acute myeloid leukemia
Disease DO ID:
 9119
Disease MeSH ID:
 D015470
Disease NCIt ID:
 C3171
Disease ICD11 ID:
 -
Disease OMIM ID:
 601626
Species: Human
Species details: Homo sapiens
Tissue specimen:

bone marrow; peripheral blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: RBPMS
Associated microRNA: -
Biological function: unknown
Molecular mechanism: RBP-associated regulatory interaction inferred from distance-correlation regulatory network; prognostic association with overall survival
Biological pathway or process:

other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; Survival Analysis
Clinical significance:

Associated with overall survival (OS) in adult AML (log-rank test; p < .02).
Description:

In high-risk adult AML (TCGA), NRIP1/circNRIP1 is identified as an upregulated circRNA target associated with RBPMS in an RBP-centered regulatory network and is prognostically associated with overall survival.
Confidence score:

0.348
Other information
Title:

Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis.

Journal: Cancer reports (Hoboken, N.J.)
Published: 2022
PubMed ID: 34862757
Study type:

bioinformatics study
Data availability: TCGA; TARGET
Code availability: -