| Expression pattern: |
DN |
| Associated gene: |
RHOB |
| Associated microRNA: |
miR-197 |
| Biological function: |
hsa_circ_0001017 inhibits gastric cancer cell proliferation, migration, invasion, metastasis-associated malignant phenotype, and tumor formation. |
| Molecular mechanism: |
hsa_circ_0001017 acts as a miR-197 sponge and promotes RHOB expression through the miR-197/RHOB signaling pathway. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); ceRNA regulation (other); other pathway/process (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0001017 may act as a biomarker and effective treatment target for gastric cancer. |
| Description: |
hsa_circ_0001017 is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-197 and promoting RHOB expression, suggesting potential therapeutic biomarker value. |
| Confidence score: |
0.6536 |