circRNA basic information
circBase ID: hsa_circ_0004293
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr11:118656760-118657227:-
Genomic location(hg38): chr11:118786051-118786518:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

NSCLC tissues; adjacent tissues
Cell lines:

BEAS-2B; A549; H23; H460; H522; H1299
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: unknown
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; Transfection; CCK8; TUNEL
Clinical significance:

potentially related to NSCLC development and LNM (candidate circRNA)
Description:

circ_0004293 was identified by microarray as down-regulated in NSCLC tissues (including LNM vs NLNM comparison) and showed lower expression in NSCLC cell lines than control cells. It was tested in vitro with overexpression, but its effects on proliferation/apoptosis were weaker than circ_0008594 and no mechanism axis was established.
Confidence score:

0.4852
Other information
Title:

Microarray Identifies a Key Carcinogenic Circular RNA 0008594 That Is Related to Non-Small-Cell Lung Cancer Development and Lymph Node Metastasis and Promotes NSCLC Progression by Regulating the miR-760-Mediated PI3K/AKT and MEK/ERK Pathways.

Journal: Frontiers in oncology
Published: 2021
PubMed ID: 34858831
Study type:

combined biological and clinical study
Data availability: https://www.frontiersin.org/articles/10.3389/fonc.2021.757541/full#supplementary-material
Code availability: -