circRNA basic information
circBase ID: hsa_circ_0008434
Name: hsa_circ_UQCRC2
Synonym: -
Host Gene: UQCRC2
Genomic location(hg19): chr16:21972648-21987564:+
Genomic location(hg38): chr16:21961327-21976243:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumour tissue; adjacent healthy tissue / paired normal gastric tissues
Cell lines:

SGC7901; MKN45; MKN28; AGS; BGC823; GES-1; 293 T
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: USP9X
Associated microRNA: miR-6838-5p / miR-6838
Biological function: promotes proliferation, migration and invasion of gastric cancer cells; promotes tumour growth in vivo
Molecular mechanism: Acts as a miRNA sponge (ceRNA) for miR-6838-5p to upregulate USP9X.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Colony Formation Assay; In Vivo Animal Model; Clinical Sample Validation
Clinical significance:

Hsa_circ_0008434 may be used as a potential biomarker for GC.
Description:

In gastric cancer, hsa_circ_0008434 is up-regulated and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA sponging miR-6838-5p to increase USP9X expression.
Confidence score:

0.7736
Other information
Title:

Hsa_circ_0008434 regulates USP9X expression by sponging miR-6838-5p to promote gastric cancer growth, migration and invasion.

Journal: BMC cancer
Published: 2021
PubMed ID: 34856948
Study type:

combined biological and clinical study
Data availability: The datasets used and/or analysed during the current study are available from the corresponding author upon reasonable request.
Code availability: -