| Expression pattern: |
UP |
| Associated gene: |
PIK3R3, PI3K/AKT pathway, Ago2 |
| Associated microRNA: |
miR-542-3p |
| Biological function: |
promotes cisplatin resistance and cell survival (reduced apoptosis) in glioblastoma cells |
| Molecular mechanism: |
ceRNA sponging of miR-542-3p to upregulate PIK3R3 and activate PI3K/AKT signaling |
| Biological pathway or process: |
PI3K/AKT (promotes); apoptosis (inhibits); proliferation (promotes); migration (promotes); drug resistance (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; divergent primers PCR; Sanger Sequencing; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; Transwell Assay; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_PTN is up-regulated in cisplatin-resistant glioblastoma cell models and promotes DDP resistance. Mechanistically, circ_PTN sponges miR-542-3p to relieve repression of PIK3R3, thereby activating PI3K/AKT signaling and reducing apoptosis under cisplatin treatment; circ_PTN knockdown sensitizes xenograft tumors to cisplatin. |
| Confidence score: |
0.8028 |