circRNA basic information
circBase ID: -
Name: hsa_circ_SAMD4A
Synonym: circ101356
Host Gene: SAMD4A
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0004992
MONDO name: cancer
Disease details: human cancer
Disease DO ID:
 0050686, 0050687, 162
Disease MeSH ID:
 -
Disease NCIt ID:
 C9305
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

normal colon mucosa
Cell lines:

HCT-116; DKO
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-330-3p, hsa-miR-660-5p
Biological function: acts as miRNA decoy
Molecular mechanism: Promoter CpG island hypermethylation of SAMD4A is linked to downregulation of SAMD4A circ101356; reactivation correlates with reduced complementary miRNAs (hsa-miR-330-3p, hsa-miR-660-5p)
Biological pathway or process:

ceRNA regulation (promotes)
Detected method:
Q
M
Validation methods:

Microarray; RNase R Treatment; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Bioinformatics Analysis
Clinical significance:

-
Description:

SAMD4A circ101356 is downregulated in methylated HCT-116 cancer cells and reactivated in DNMT-deficient DKO cells. Its reactivation is associated with reduced levels of complementary miRNAs (hsa-miR-330-3p and hsa-miR-660-5p), supporting a miRNA-decoy mechanism.
Confidence score:

0.5193
Other information
Title:

Circular RNA CpG island hypermethylation-associated silencing in human cancer.

Journal: Oncotarget
Published: 2018
PubMed ID: 30018746
Study type:

combined biological and clinical study
Data availability: GSE109676
Code availability: -