circRNA basic information
circBase ID: hsa_circ_0005797
Name: hsa_circ_ATP2C1
Synonym: -
Host Gene: ATP2C1
Genomic location(hg19): chr3:130649259-130660543:+
Genomic location(hg38): chr3:130930415-130941699:+
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0011962
MONDO name: endometrial cancer
Disease details: endometrial cancer
Disease DO ID:
 1380
Disease MeSH ID:
 -
Disease NCIt ID:
 C27815
Disease ICD11 ID:
 -
Disease OMIM ID:
 608089
Species: Human
Species details: Homo sapiens
Tissue specimen:

EC tissue; normal endometrial samples; xenograft tumors
Cell lines:

HEC-1-B; AN3-CA; KLE; HEC1-A; Ishikawa; HEEC
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: CTNND1
Associated microRNA: miR-298
Biological function: promotes proliferation and invasion; facilitates tumor growth in vivo
Molecular mechanism: Acts as a miR-298 sponge to regulate CTNND1 expression (ceRNA axis).
Biological pathway or process:

proliferation (promotes); invasion (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model
Clinical significance:

High hsa_circ_0005797 expression is associated with advanced FIGO staging and lymph node metastasis, and is a poor prognostic factor for EC.
Description:

In endometrial cancer, hsa_circ_0005797 is up-regulated and promotes proliferation, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-298, thereby relieving repression of CTNND1 and activating the miR-298/CTNND1 axis. High expression is associated with aggressive clinicopathologic features and poor prognosis.
Confidence score:

0.8462
Other information
Title:

Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling.

Journal: Bioengineered
Published: 2022
PubMed ID: 34852711
Study type:

combined biological and clinical study
Data availability: available from the corresponding author on reasonable request
Code availability: -