circRNA basic information
circBase ID: hsa_circ_0063309
Name: hsa_circ_DDX17
Synonym: -
Host Gene: DDX17
Genomic location(hg19): chr22:38879442-38889776:-
Genomic location(hg38): chr22:38483437-38493771:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0008487
MONDO name: polycystic ovary syndrome
Disease details: polycystic ovary syndrome
Disease DO ID:
 11612
Disease MeSH ID:
 D011085
Disease NCIt ID:
 C26862
Disease ICD11 ID:
 1213633323
Disease OMIM ID:
 184700
Species: Human
Species details: Homo sapiens
Tissue specimen:

cumulus cells
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CASP2, FZD4, HMGCR, TAB2, PEA15, RUNX2, PAK3, MBNL2
Associated microRNA: hsa-miR-139-5p, hsa-miR-217, hsa-miR-346, hsa-miR-421
Biological function: May be involved in inflammation-mediated cell apoptosis and steroidogenesis in cumulus cells in PCOS.
Molecular mechanism: Predicted ceRNA (miRNA sponge) regulation of downstream genes; predicted interaction with RBP (MBNL2).
Biological pathway or process:

ceRNA regulation (other); apoptosis (other); steroidogenesis (other); inflammation (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0063309 is an upregulated hub circRNA in PCOS cumulus cells identified by microarray reanalysis and WGCNA. It is predicted to act as a miRNA sponge (e.g., hsa-miR-139-5p/217/346/421) to affect apoptosis/inflammation- and steroidogenesis-related targets (e.g., CASP2, FZD4, HMGCR, TAB2, PEA15, RUNX2, PAK3), and to interact with the RBP MBNL2.
Confidence score:

0.1768
Other information
Title:

WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs.

Journal: International journal of general medicine
Published: 2021
PubMed ID: 34849014
Study type:

bioinformatics study
Data availability: GSE145296; GSE72274; GSE155489
Code availability: -