| Expression pattern: |
UP |
| Associated gene: |
CRIM1, ZEB2 |
| Associated microRNA: |
miR-145-5p, miR-383-5p |
| Biological function: |
Promotes ovarian cancer cell viability, migration and invasion, inhibits apoptosis, and promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA to positively regulate CRIM1 via sponging miR-145-5p; binds miR-383-5p to up-regulate ZEB2. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; MTT; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
CircCRIM1 is up-regulated in ovarian cancer and promotes malignant phenotypes (viability/proliferation, migration, invasion) while inhibiting apoptosis, and enhances tumor growth in xenografts. Mechanistically, it acts as a ceRNA for CRIM1 via miR-145-5p and also binds miR-383-5p to increase ZEB2 expression. |
| Confidence score: |
0.7875 |