| Expression pattern: |
UP |
| Associated gene: |
S100B, Ago2 |
| Associated microRNA: |
miR-1182 |
| Biological function: |
Promotes ovarian cancer cell proliferation, glycolysis metabolism, migration and invasion; attenuates Propofol-mediated inhibition; promotes tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA/miRNA sponge for miR-1182, thereby relieving miR-1182-mediated repression of S100B and promoting S100B expression. |
| Biological pathway or process: |
proliferation (promotes); glycolysis (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Back-Splice Junction PCR / divergent primers PCR; Transfection; MTT; Colony Formation Assay; Transwell Assay; Wound Healing Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model |
| Clinical significance: |
- |
| Description: |
circ_MUC16 is up-regulated in ovarian cancer tissues/cell lines and mainly localizes to the cytoplasm. It attenuates Propofol’s anti-tumor effects by sponging miR-1182 and thereby increasing S100B, promoting proliferation, glycolysis, migration, invasion, and tumor growth. |
| Confidence score: |
0.7983 |