circRNA basic information
circBase ID: hsa_circ_0000075
Name: -
Synonym: circ_0000075
Host Gene: -
Genomic location(hg19): chr1:59787207-59812070:+
Genomic location(hg38): chr1:59321535-59346398:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007576
MONDO name: esophageal cancer
Disease details: Esophageal cancer
Disease DO ID:
 5041
Disease MeSH ID:
 -
Disease NCIt ID:
 C7478
Disease ICD11 ID:
 669033105
Disease OMIM ID:
 133239
Species: Human
Species details: Homo sapiens
Tissue specimen:

ESCC tissues; adjacent normal tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: mRNAs
Associated microRNA: hsa-miR-31-5p, hsa-let-7i-5p, hsa-miR-4644, hsa-miR-105-5p, hsa-miR-370-3p, hsa-miR-544a, hsa-miR-17-3p
Biological function: involved in regulating zinc II ion transport, transition metal ion homeostasis, angiogenesis, blood vessel development, extrinsic apoptotic signaling pathway, response to amino acid, nucleocytoplasmic transport, response to acid chemical, toll-like receptor 4, cellular response to hepatocyte growth factor stimulus, chemotaxis transforming, and growth factor beta2 production
Molecular mechanism: Predicted ceRNA network (circRNA-miRNA-mRNA) based on bioinformatics analysis
Biological pathway or process:

angiogenesis (other); apoptosis (other); immune regulation (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0000075 was identified as a key circRNA in ESCC based on RNA-seq and bioinformatics network analysis. Enrichment suggested associations with angiogenesis/blood vessel development and extrinsic apoptotic signaling-related processes.
Confidence score:

0.1768
Other information
Title:

Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.

Journal: Computational and mathematical methods in medicine
Published: 2020
PubMed ID: 32908582
Study type:

bioinformatics study
Data availability: available from the corresponding author upon request
Code availability: -