| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR-1178 |
| Biological function: |
Inhibits OSCC metastatic properties including proliferation, migration, and invasion; associated with absence of regional lymph node metastasis. |
| Molecular mechanism: |
circRNA-102450 binds miR-1178 and down-regulates it (miRNA sponge/negative regulation). |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RT-ddPCR; divergent primers PCR; RNase R Treatment; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; Transfection; Transwell Assay; Wound Healing Assay; Cohort Study |
| Clinical significance: |
High circRNA-102450 in preoperative plasma liquid biopsy was associated with no regional lymph node metastasis; proposed as a potential biomarker predicting RLNM in OSCC. |
| Description: |
circRNA-102450 is down-regulated in OSCC cells and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration and invasion, and it directly binds to and down-regulates miR-1178. In preoperative plasma liquid biopsy, low circRNA-102450 is associated with regional lymph node metastasis, supporting its potential diagnostic value for RLNM prediction. |
| Confidence score: |
0.8347 |