circRNA basic information
circBase ID: hsa_circ_0007312
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr22:24698162-24709434:+
Genomic location(hg38): chr22:24302194-24313466:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

PC9; PC9/ER
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MAPK1, AGO2
Associated microRNA: miR-764
Biological function: May play key roles in EGFR-TKI resistance.
Molecular mechanism: ceRNA network involving circ-0007312 interacting with miR-764 and regulating MAPK1.
Biological pathway or process:

chemoresistance (promotes); ceRNA regulation (promotes); MAPK (promotes)
Detected method:
Q
M
Validation methods:

Microarray; Bioinformatics Analysis; RT-qPCR; RIP (RNA Immunoprecipitation); Clinical Sample Validation
Clinical significance:

circ-0007312 can be detected in plasma and may have the potential to be a novel disease progression biomarker in lung adenocarcinoma patients.
Description:

circ-0007312 (hsa_circ_0007312) is up-regulated in EGFR-TKI-resistant PC9/ER lung adenocarcinoma cells and is proposed to function in a ceRNA network by interacting with miR-764 to affect MAPK1. It is detectable in patient plasma and may serve as a disease progression biomarker related to EGFR-TKI resistance.
Confidence score:

0.5135
Other information
Title:

Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance.

Journal: Technology in cancer research & treatment
Published: 2021
PubMed ID: 34825849
Study type:

combined biological and clinical study
Data availability: Supplemental material for this article is available online.
Code availability: -