| Expression pattern: |
UP |
| Associated gene: |
E-cadherin, N-cadherin |
| Associated microRNA: |
miR-218-5p |
| Biological function: |
circFOXM1 promotes proliferation, clone formation and migration and inhibits apoptosis of glioma cells; circFOXM1 silencing blocks proliferation, clone formation and migration and induces apoptosis through upregulating miR-218-5p. |
| Molecular mechanism: |
circFOXM1 targets and adsorbs miR-218-5p, negatively regulating miR-218-5p levels; circFOXM1 silencing increases miR-218-5p and alters E-cadherin and N-cadherin expression. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); migration (promotes); EMT (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; MTT; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot |
| Clinical significance: |
CircFOXM1 may be a latent target for molecular targeted therapy of glioma. |
| Description: |
This study found that circFOXM1 is upregulated in glioma tissues and promotes malignant glioma cell behaviors. Mechanistically, circFOXM1 targets and negatively regulates miR-218-5p, and circFOXM1 silencing suppresses proliferation, colony formation and migration while promoting apoptosis, with associated changes in E-cadherin and N-cadherin. The authors suggest circFOXM1 may be a potential molecular therapeutic target for glioma. |
| Confidence score: |
0.6278 |